What if the world was so strange that we could never hope to understand it?

This is one of the implications suggested by Stephen Hawking's "Information Paradox" more than three decades ago. It does seem that even is such precise disciplines as physics, the more abstract things become, the higher level you go, the harder it is for us to reach a consensus on what the reality really is. Modern science is already challenging complex enough questions that require a very long time to come up with an answer for (and even then not everybody is on board or completely satisfied). The scientific community in effectively divided in ideologically opposing camps for years and years because nobody can just "measure" the absolute answer anymore and it's always less and less trivial than it used to be. Take this Information Paradox for example, Hawking for 30 years was absolutely convinced that everything that enters a black hole simply disappears. That was contrary to what most physicists believe that no information is truly lost no matter what happens to it. String theory can be another good example of ideological division in opposing camps. The problem is we simply cannot experimentally prove it one way or another at the moment. Generally speaking this would be fine, as beliefs (or ideas or theories or hypotheses) would just be a temporary state until we learn to do so (prove or dis-prove them that is), however what if the world is simply beyond our compensation and we never really get there? Doesn't this turn science into just another religion? After all one can never disprove the existence of God either.

There's people that don't bother searching for answers, because of whatever reasons. Does this mean they had the instinct to realize the above speculation all along (even if it were unconsciously) and it is we the ones that do search wasting our time?